Published 28 September 2026. Product facts were checked against Mammotome documentation on 28 September 2026. Written by the Medical Outfitters sales and field engineering team; Medical Outfitters is an authorized Mammotome dealer.
A complete Neoprobe Gamma Detection System costs $85,000 to $145,000 in 2026, delivered, set up, with applications training and the warranty included: the Model 2400 console, one Bluetooth probe and the cart. A console on its own runs $52,000 to $80,000, each additional 10 mm or 14 mm Bluetooth probe adds $22,000 to $33,000, and a two-room program with two consoles and three or four probes lands at $160,000 to $265,000. Mammotome publishes no list price, so every system is quoted as a configuration; Medical Outfitters, an authorized Mammotome dealer, returns the priced configuration within one business day of a quote request.
This guide explains what a gamma detection system costs in practice: our ranges by configuration, what a Neoprobe quote is made of, which lines move the price, what the five current probes are for, new versus refurbished versus used, what it costs to run, who buys one and how to buy it. Product facts are Mammotome’s, checked 28 September 2026.
How Much Does a Neoprobe Cost?
There is no single Neoprobe price because there is no single Neoprobe. The Mammotome Neoprobe Gamma Detection System is sold as a control unit plus the probes a surgical program chooses, and the same console can leave with one corded probe or with three wireless probes, a cart and a collimator. The manufacturer sets dealer pricing per configuration and publishes no list price. The ranges below are Medical Outfitters ranges for a system delivered and set up, with applications training and the manufacturer warranty included, and every configuration is quoted individually.
| Configuration | Medical Outfitters range, 2026 | What moves it |
|---|---|---|
| Model 2400 console alone (NPCU4) | $52,000 to $80,000 | Software level; one console per operating room in use at the same time |
| Complete system: console, one Bluetooth probe, cart | $85,000 to $145,000 | Probe size and type, cart, applications training |
| Each additional Bluetooth probe, 10 mm or 14 mm | $22,000 to $33,000 | Straight or angled; the probe count moves the quote most |
| Transport cart (NEOCART1) | $7,500 to $9,000 | Optional; some sites shelf-mount the console |
| Two-room program: two consoles, three or four probes | $160,000 to $265,000 | Console count, probe mix, accessories |
| Refurbished or used system, earlier-generation console | $35,000 to $95,000 | Console generation, which probes are included, warranty source |
A refurbished or used system typically saves 20 to 60 percent against new, and on a Neoprobe the saving depends on the console generation and which probes come with it. Our ranges include delivery, set-up, applications training, warranty support and the cost of doing business in 2026; a bare equipment price from a reseller is not the same number.
| Quote line | What it is | Why it moves the price |
|---|---|---|
| Control unit | Neoprobe GDS control unit with software (NPCU4); the console that turns counts into a number and a tone | One per operating room that runs radio-guided cases at the same time |
| Bluetooth probes | 10 mm or 14 mm reusable wireless probes, straight or angled | Each probe is its own line; one to three per console is typical |
| Corded probe | 14 mm reusable corded probe (NPR14), powered through its cable | The lower-cost entry; it runs on wireless or non-wireless consoles |
| Cart | Neoprobe GDS cart (NEOCART1) with locking castors and a probe and accessory drawer | Optional; some sites shelf-mount the console |
| Accessories | External collimator for the 14 mm probes (NPE14), check source holder (P-405) | Small lines, specified by the surgical team |
| Delivery, training, warranty | Delivery, applications training and the manufacturer warranty | Included in a Medical Outfitters quote; priced separately by some resellers |
The same question arrives in many forms: Neoprobe cost, Neoprobe price, Neoprobe machine cost, Neoprobe GDS price, gamma probe cost, gamma probe price, gamma detection system cost, how much does a Neoprobe cost. They all resolve to the table above. Tell us the procedures and the number of operating rooms and the quote writes itself.
Why there is no list price for a Neoprobe
Three reasons. The system is modular, so the configuration decides the price before anything else. Mammotome sells through authorized dealers, who quote per site. And the probes, which are the expensive part, are chosen for the case mix: a breast program that does sentinel node biopsy all day specifies differently from a melanoma or parathyroid service that adds an angled probe for access. That is why our ranges are given by configuration, and why the quote for your program will sit at a specific point inside them.
How to get a Neoprobe price in one business day
Send us the procedures you perform, the number of operating rooms that run radio-guided cases at the same time, and whether you want wireless probes, the corded probe or both. We return the configuration priced, with delivery, training and the warranty stated. Request a Neoprobe quote »
What a Neoprobe System Includes
A gamma detection system has two halves that are bought and, when needed, serviced separately: the control unit and the probes. Everything else is an accessory. The current system, per Mammotome, is:
- Control unit. The current console is the Model 2400 (catalog number NPCU4, per the FDA device registry); the 2300 and the neo2000 are the earlier generations seen on the resale market. It detects five isotopes, 99mTc, 125I, 57Co, 111In and 131I, plus an open setting, with a dual-isotope mode that reads 99mTc and 125I at the same time. Starts with no calibration and has no preventive maintenance schedule. A one-touch remote count works from inside the sterile field.
- Wireless Bluetooth probes. 10 mm and 14 mm heads, each straight or angled. The probes report individual isotope counts to the console in real time.
- Corded 14 mm probe (NPR14). Powered through the cable, sterilizable, and compatible with wireless and non-wireless consoles, which is why it also keeps older systems in service.
- Cart. Medical-grade locking castors and a built-in probe and accessory drawer; 20 by 22 by 42 inches (W by L by H), about 28 lb.
- Accessories. An external collimator for the 14 mm probes, to tighten directionality, and a check source holder.
Theatre staff call the console the Neoprobe machine and the handpiece the Neoprobe probe. The console is the capital item; the probes are what wear, get sterilized and, on a used system, need the closest look. What a Neoprobe is explains how gamma detection guides the surgeon; the product page carries the full specification.
The Five Neoprobe Probes and Which to Buy
Five reusable probes make up the current lineup. Which ones you buy sets more of the price than any other decision, so it pays to match them to the procedures rather than to buy the largest set.
| Probe | Connection | What Mammotome states | Buy it for |
|---|---|---|---|
| 10 mm straight | Bluetooth | 28.6% smaller head diameter than the 14 mm; internally collimated for spatial resolution; STERRAD and STERIS compatible | Lymphatic mapping through smaller incisions, better anatomical visibility |
| 10 mm angled | Bluetooth | Same head and sterilization as the straight 10 mm, on an angled shaft | Access at an angle in the axilla and neck |
| 14 mm straight (NPB14S) | Bluetooth | 50% more sensitive than the NPR14 corded probe; works with or without the external collimator | The workhorse sentinel node probe for breast programs |
| 14 mm angled (NPB14A) | Bluetooth | The 14 mm head on an angled shaft; external collimator optional | Deeper or angled targets, parathyroid and melanoma work |
| 14 mm corded (NPR14) | Corded | Integrated power through the cable; compatible with wireless or non-wireless consoles; sterilizable | The lowest-cost entry, a backup probe, or an older console |
Source: Mammotome Neoprobe product page and the September 2025 launch note for the 10 mm probes. Earlier-generation 9 mm and 11 mm laparoscopic Bluetooth probes are no longer in the current lineup; if you own them, ask before assuming they pair with a new console.
How many probes does a program need?
One console can pair with several probes, but a probe in the sterilizer is a probe you cannot use, so the practical question is how many cases run back to back. A single-room breast program usually starts with one 14 mm Bluetooth probe and adds a second wireless probe, often the 10 mm or an angled 14 mm, once turnover or a second surgeon demands it. Two rooms running at once need two consoles, not just two probes. The corded NPR14 is the inexpensive way to keep a backup on hand.
What Moves the Price of a Gamma Detection System
Two quotes for the same console can differ by a whole probe or a whole cart. These are the lines that move a gamma detection system price, roughly in order of impact.
- Number of probes Each Bluetooth probe is its own line; one, two or three per console
- Probe type 10 mm or 14 mm, straight or angled, wireless or corded
- Number of consoles One control unit per operating room running radio-guided cases at the same time
- Condition New from an authorized dealer, or an earlier-generation console from the resale market
- Accessories Cart, external collimator for the 14 mm probes, check source holder
- Warranty, training and delivery Included in our quote; priced separately by some resellers
New, Refurbished or Used Neoprobe: What You Get
The condition question on a Neoprobe is really a generation question. A new system from an authorized dealer is the current control unit with the current probes, the manufacturer warranty and applications training. On the resale market, earlier consoles circulate, among them the neo2000 and the 2300-series units that appear on equipment listing sites, and the buyer has to check what pairs with what.
What to check before buying a used Neoprobe
- Console generation and software revision: which probes it pairs with, and whether Bluetooth is supported at all
- Which probes are included: a console without a probe is not a working system; confirm the corded NPR14 or a wireless probe ships with it
- Probe condition: head and shaft condition, sterilization cycle history, and a count check against a check source before you pay
- Warranty: a reseller warranty is not the manufacturer warranty, and very little on the system is field-repairable
- Regulatory paperwork: the device history and any recalls or field notices for that console generation
Medical Outfitters supplies the Neoprobe new as an authorized Mammotome dealer, with the probe configuration matched to your procedures. If you are replacing a system, we buy used imaging and surgical equipment and can take the old console against the new one.
What It Costs to Run a Neoprobe
The Neoprobe is one of the cheaper capital items in an operating room to keep running, for a specific reason: per Mammotome, the system requires no calibration and no preventive maintenance. There is no annual service visit to budget and no calibration source to track.
- Sterilization The probes are reusable; the 10 mm probes are STERRAD and STERIS compatible and the corded probe is sterilizable. Sterilization capacity, not the probe, is the daily constraint
- Probe replacement Probes are the wear item; a dropped or damaged probe is the most common large cost over the system’s life
- Repairs Very little on the system is field-repairable; repairs go back through the manufacturer’s service program, which we coordinate for our customers
- Radiotracer and nuclear medicine The tracer is supplied and injected by nuclear medicine under its own license; the probe itself carries no radioactive source
- Check source Sites that verify probe response before a case keep a check source in the holder; it is a separate purchase
What a Gamma Probe Is and Who Buys One
A gamma probe is a handheld detector that tells a surgeon, during the operation, which tissue is emitting radiation from a radiotracer injected beforehand. It produces no image, only a count rate and a tone that rises as the probe nears the source. The Neoprobe is Mammotome’s brand of gamma detection system; the generic terms are gamma probe, gamma detection system and, for the procedure, radio-guided surgery.
What surgeons use it for
Per Mammotome, the system is used for lesion localization and sentinel lymph node biopsy in breast care, and beyond the breast for sentinel node biopsy in melanoma, parathyroid and other cancers. The dual-isotope mode matters in breast programs that use radioactive seed localization alongside a technetium tracer, because the console separates the seed from the injection site in real time. What a Neoprobe is walks through the procedure.
Who buys one
- Hospitals and surgical oncology departments running breast, melanoma and endocrine programs
- Ambulatory surgery centers that perform sentinel lymph node biopsy
- Breast centers that pair the probe with a biopsy system such as the Mammotome Revolve and mammography
- Veterinary and research surgical programs, sourced on request
Building or expanding a breast program? The mammography machine cost guide covers the imaging side and the PET/CT scanner cost guide covers nuclear medicine imaging; the Neoprobe is the operating-room end of the same pathway.
How to Buy a Neoprobe
- List the procedures. Sentinel node biopsy, seed localization, parathyroid, melanoma: the case mix decides the probes.
- Count the rooms. One console per operating room that runs radio-guided cases at the same time.
- Choose the probes. Start with a 14 mm Bluetooth probe; add a 10 mm or an angled probe for access; keep a corded NPR14 as the backup if turnover is high.
- Decide the cart and accessories. Cart for a shared console, external collimator if the surgeons want it, check source holder if the department verifies response.
- Get the configuration in writing. Control unit, each probe by size and type, cart, accessories, delivery, training and warranty, so quotes compare line by line.
- Coordinate with nuclear medicine. Tracer supply, injection timing and the radiation safety officer’s sign-off are on their side of the pathway.
- Schedule training. Applications training for the surgical team is included in our quote and takes one visit.
We quote within one business day and deliver, train and support across the United States, Puerto Rico and the Caribbean through an ISO 13485:2016 certified quality system. Request a Neoprobe quote »
Frequently Asked Questions
- How much does a Neoprobe cost?
- A complete Neoprobe system, the Model 2400 console with one Bluetooth probe and the cart, costs $85,000 to $145,000 in 2026 delivered, set up, with applications training and the warranty included. A console alone is $52,000 to $80,000, each additional 10 mm or 14 mm Bluetooth probe adds $22,000 to $33,000, and a two-room program with two consoles and three or four probes is $160,000 to $265,000.
- Does Mammotome publish a Neoprobe price list?
- No. Pricing is set per configuration through authorized dealers such as Medical Outfitters, which is why resale listings and dealer quotes are not comparable until the probes, the console generation and the warranty are lined up. Our ranges are given by configuration and every system is quoted individually.
- What is included in a Neoprobe quote?
- The Neoprobe GDS control unit with software, each probe by size and type, the cart if you want one, accessories such as the external collimator and check source holder, and, in a Medical Outfitters quote, delivery, applications training and the manufacturer warranty.
- How many probes do I need?
- A single-room program usually starts with one 14 mm Bluetooth probe and adds a second wireless probe, often a 10 mm or an angled 14 mm, when turnover or a second surgeon demands it. Two rooms running radio-guided cases at once need two consoles. The corded NPR14 is the inexpensive backup.
- What is the difference between the 10 mm and 14 mm Neoprobe probes?
- Per Mammotome, the 10 mm Bluetooth probes have a 28.6% smaller head diameter than the 14 mm, are internally collimated for spatial resolution and support smaller incisions in lymphatic mapping; the 14 mm Bluetooth probes are 50% more sensitive than the NPR14 corded probe and take an optional external collimator. Both come straight or angled.
- Are the Neoprobe probes wireless?
- The 10 mm and 14 mm probes connect to the console over Bluetooth and report individual isotope counts in real time, with a one-touch remote count from inside the sterile field. A corded 14 mm probe, the NPR14, is also available and runs on wireless or non-wireless consoles.
- What isotopes does the Neoprobe detect?
- Five isotopes, 99mTc, 125I, 57Co, 111In and 131I, plus an open setting, with a dual-isotope mode that reads 99mTc and 125I at the same time so the console can separate a radioactive seed from the tracer injection site.
- Does a Neoprobe need calibration or preventive maintenance?
- No. Per Mammotome, the system requires no calibration and no preventive maintenance and starts with no calibration step, which is why its running cost is largely sterilization and the occasional probe replacement.
- Can I buy a used or refurbished Neoprobe?
- Yes. A refurbished or used system with an earlier-generation console runs $35,000 to $95,000 depending on the console and the probes included, typically 20 to 60 percent below new. Check the console generation and software revision, which probes it pairs with and whether Bluetooth is supported, the probes’ condition and sterilization history, and what the reseller warranties. Medical Outfitters supplies the system new as an authorized Mammotome dealer and quotes refurbished and used units on request.
- Is the corded probe compatible with the wireless console?
- Yes. Per Mammotome, the 14 mm corded NPR14 probe is compatible with wireless and non-wireless consoles, which makes it a useful backup on a new system and the probe that keeps older consoles in service.
- What does a Neoprobe cost to run?
- Sterilization of the reusable probes, an occasional probe replacement, and a check source if the department verifies response before cases. There is no calibration and no preventive maintenance schedule, and the radiotracer is supplied by nuclear medicine under its own license.
- Does Medical Outfitters service the Neoprobe?
- We supply the system new, deliver it, train the surgical team and coordinate manufacturer service for our customers. Very little on the Neoprobe is field-repairable, so repairs run through Mammotome’s service program rather than an on-site visit.
- What is a gamma probe?
- A handheld detector used during surgery to find tissue that is emitting radiation from an injected radiotracer, most often the sentinel lymph node in breast cancer and melanoma. It gives the surgeon a count rate and a rising tone, not an image. Neoprobe is Mammotome’s brand of gamma detection system.
- Where can I buy a Mammotome Neoprobe?
- Through an authorized Mammotome dealer, because the console, the probes and the accessories are sold and supported as a system. Medical Outfitters is an authorized dealer, ISO 13485:2016 certified, and quotes, delivers and trains across the United States, Puerto Rico and the Caribbean.
- Is the Neoprobe FDA cleared?
- Yes. The Neoprobe Gamma Detection System, made by Devicor Medical Products under the Mammotome name, is FDA cleared for use in radio-guided surgery.
Medical Outfitters sells new Fujifilm, Esaote and Mammotome systems as an authorized dealer and certified refurbished GE and Siemens systems through MO Select, with delivery and installation included in every quote. Browse biopsy and surgical oncology equipment for sale, browse used and refurbished MRI machines for sale, browse CT scanners for sale and browse X-ray machines for sale; every listing shows the model, condition and availability with a quote form.
Tell us the procedures and the rooms. Medical Outfitters, an authorized Mammotome dealer, returns the control unit, probes, accessories, delivery, training and warranty priced as one quote. Serving the US, Puerto Rico, and the Caribbean.
